胶质母细胞瘤

胶质母细胞瘤 may be treated both medically within our 脑瘤 & Neuro Oncology Program and surgically at our 推荐最近最火的赌博软件 Brain and 脊柱中心.

About 胶质母细胞瘤

定义

胶质母细胞瘤 IDH wild type (GBM IDHwt) is the most common infiltrating glioma. Glioma is a type of 大脑 癌症 whose cells soak into normal 大脑 组织.

脑瘤

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原因

Cancer is when cells grow out of control. The cells can form a clump of 组织 called a growth or tumor. Cancer cells can invade nearby 组织s. 它可以 then spread to other parts of the body. It is not clear what causes this.

风险因素

The chances of GBM are higher for people who:

• Are aged 50 years or more
• Are White, Hispanic, or Asian
• Have rare inherited diseases such as Li-Fraumeni syndrome or neurofibromatosis 1型
• Were exposed to radiation to the head
• Were possibly exposed to some types of harmful chemicals

症状

症状 depend on the tumor's size and where it is. 他们可能 包括:

• 症状 caused by growing pressure to the 大脑:
  • 头痛
  • Nausea or vomiting
  • 复视
  • 睡意
• 症状 caused by where the tumor is:
  • 弱点
  • 麻木
  • Problems speaking
  • Problems thinking
  • Vision problems
  • Problems walking
  • 癫痫发作

诊断

The doctor will ask about symptoms and health history. 一个医生 may also want to do:

• Imaging tests such as:
  • 核磁共振成像扫描
  • MR spectroscopy scan
  • PET扫描
  • CT扫描
• 脑电图描记器—to test the electrical activity of the 大脑.
• 活组织检查 or resection—some of the tumor is removed and tested. This can help doctors learn more about it and make a treatment 计划.
• Lumbar puncture—to test the fluid that surrounds the 大脑 and spinal cord. This is not done as often for GBM IDHwt.

治疗

Surgery is often done to confirm a diagnosis and to remove as much of the tumor as possible. All of the tumor cannot be taken out with surgery. 其他 ways to manage GBM IDHwt are:

• Radiation therapy—to shrink the tumor
• 化疗—to improve length and quality 的生活
• Tumor treating fields

GBM is very hard to treat. It may come back after being removed. It often causes death. A person who has GBM IDHwt may be advised to find:

• Support groups
• 咨询
• Someone to help with end 的生活 计划ning
• 临终关怀

预防

GBM IDHwt cannot be prevented.

参考文献

• Adult central nervous system tumors treatment (PDQ®)-health professional version. National Cancer Institute 网站. Available at: http://www.癌症.gov/types/大脑/hp/adult-大脑-treatment-pdq.
• 脑部肿瘤. American Association of Neurological Surgeons 网站. Available at: http://www.感染。.org/en/Patients/Neurosurgical-条件-and-治疗s/Brain-Tumors.
• 胶质母细胞瘤. EBSCO DynaMed 网站. Available at: http://www.力学.com/condition/glioblastoma.
• Horbinski C.利根，K.L.等。. The medical necessity of advanced molecular testing in the diagnosis and treatment of 大脑 tumor patients. Neuro-Oncology, 2019; 21 (12): 1498-1508.
• 卢卡斯,R.V., Wainwright, D.A.等。. Newly diagnosed glioblastoma: a review on clinical management. Oncology (Williston Park), 2019; 33 (3): 91-100.
• 卢卡斯,R.V. and Mrugala, M.M. Pivotal therapeutic trials for infiltrating gliomas and how they affect clinical practice. Neuro Oncology Practice, 2017; 4 (4): 209-219.
• 粗汞华,R.W .梅森.P.等。. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal of Medicine, 2005; 352 (10): 987-996.
• 粗汞华,R., Taillibert, S.等。. Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA, 2017; 18 (23): 2306-2316.